Silencing of long non-coding RNA HCP5 inhibits proliferation, invasion, migration, and promotes apoptosis via regulation of miR-299-3p/SMAD5 axis in gastric cancer cells
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چکیده
منابع مشابه
Silencing of the long non-coding RNA NEAT1 suppresses ovarian cancer cell proliferation, migration and invasion
Increasing evidence reveals that long noncoding RNAs (lncRNAs) are involved in the development of various human cancers including ovarian cancer. LncRNA nuclear enriched abundant transcript 1 (NEAT1) is an essential structural determinant of nuclear body paraspeckles. Although aberrant expression and prognostic value of NEAT1 has been recently reported in various human cancers, NEAT1 was not fu...
متن کاملDown-regulation of long non-coding RNA TUG1 inhibits osteosarcoma cell proliferation and promotes apoptosis.
OBJECTIVE To investigate the expression level of TUG1 and one of its transcript variants (n377360) in osteosarcoma cells and assess the role of TUG1 in proliferation and apoptosis in the U2OS cell line. METHODS TUG1 and n377360 expression levels in patients with osteosarcomas and the U2OS human osteosarcoma cell line were evaluated using real-time quantitative PCR. U2OS cells were transected ...
متن کاملLong non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer
Abnormal expression of long non-coding RNA (lncRNAs) often contributes to unrestricted growth and invasion of cancer cells. LncRNA XIST expression is up-regulated in several cancers, however, its modulatory mechanism in gastric cancer (GC) has not been elucidated. In the present study, we found that XIST expression was significantly increased in GC tissues and cell lines. LncRNA XIST promoted c...
متن کاملLong non-coding RNA TUG1 promotes endometrial cancer development via inhibiting miR-299 and miR-34a-5p
It is generally known that the human genome makes a large amount of noncoding RNAs compared with coding genes. Long non-coding RNAs (lncRNAs) which composed of more than 200 nucleotides have been described as the largest subclass of the non-coding transcriptome in human noncoding RNAs. Existing research shows that lncRNAs exerted biological functions in various tumors via participating in both ...
متن کاملMiR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC
Objective(s):MiRNAs have been proposed to be key regulators of tumorigenesis, progression and metastasis. However, their effect and prognostic value in gastric cancer is still poorly known. Materials and Methods: Gastric cancer cell lines were cultured. Tissue samples obtained from 36 gastric cancer patients were used for quantitative real-time PCR (qRT-PCR) analysis. The tissue microarrays (T...
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ژورنال
عنوان ژورنال: Bioengineered
سال: 2020
ISSN: 2165-5979,2165-5987
DOI: 10.1080/21655979.2020.1863619